Interstitial cells of Cajal, from structure to function
نویسندگان
چکیده
منابع مشابه
Interstitial cells of Cajal, from structure to function
1 Department of Medicine, Farncombe Family Intestinal Health Research Institute, McMaster University, Hamilton, ON, Canada 2 Department of Gastroenterology and Hepatology, Wuhan University Institute of Digestive and Liver diseases, Renmin Hospital of Wuhan University, Wuhan, China 3 Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark *Correspondence: hui...
متن کاملInterstitial cells of Cajal and intestinal function in Trinidadian children.
OBJECTIVE This study was carried out to compare the density of the interstitial cells of Cajal (ICCs) in the bowel wall of children with Hirschsprung's disease (HD), anorectal malformations (ARM) and normal controls in Trinidad and Tobago. SUBJECTS AND METHOD Segments of bowel wall excised from eight children with HD, three controls and two children with ARM were immunostained with c-Kit prim...
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This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastro-intestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in as well as in GI stromal tumours are reviewed,...
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Disruptions of networks of interstitial cells of Cajal (ICC), gastrointestinal pacemakers and mediators of neurotransmission, can lead to disordered phasic contractions and peristalsis by reducing and uncoupling electrical slow waves. However, detailed analysis of the ICC network behavior has been hampered by their scarcity, limited accessibility in intact tissues, and contamination with other ...
متن کاملInterstitial cells of Cajal in enteric neurotransmission.
Specialised cells known as interstitial cells of Cajal (ICCs), distributed in specific locations within the tunica muscularis of the gastrointestinal tract, serve as electrical pacemakers and mediators of enteric neurotransmission. Until recently, evidence to support a functional role of these cells has been, for the most part, indirect. The role of ICCs in pacemaking or neurotransmission has b...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2013
ISSN: 1662-453X
DOI: 10.3389/fnins.2013.00043